The reason, experts explain, is that while Differin offers one of the best forms of defense against breakouts, it isn't nearly as effective on existing blemishes. Topical retinoids, like Differin Gel, play a crucial role in the treatment of acne. In 1925, studies linked abnormal cell turnover to vitamin A deficiencies. Unlike other acne treatments you can buy in stores, Differin contains the first OTC Rx-strength acne-fighting retinoid. Retinoids play a crucial role in the treatment of acne by regulating skin cell turnover & reducing inflammation deep in the skin to clear & prevent pimples. Highlights. Clear and prevent acne with an Rx-strength retinoid; Fights the main causes of acne by regulating skin cell turnover & reducing inflammation deep in the skin to clear and prevent pimples, blackheads and clogged pores 1. You have no idea what a retinoid is. The term describes vitamin A derivatives that unclog pores, boost collagen to reduce fine lines, and speed cell turnover to even out discoloration and smooth the skin—sometimes in as little as four weeks. Differin and Duac are brand name topical acne medications prescribed to people with severe, hard-to-treat acne. Differin, also known as adapalene, is a vitamin-A derivative that prevents pimples from forming by promoting cell turnover in pores and preventing follicles from clogging. 4 tips to keep your skin healthy with Differin® Gel 1 // Apply Differin® Gel as directed Differin® Gel has a long-standing heritage as a proven acne treatment, but it is now in the OTC acne section in the beauty aisle at Target. Differin is a prescription strength retinoid acne treatment, and you used to need a prescription for it. Now, it's on Amazon for $25. I tried it and it worked wonders on my acne. Medical uses. Per the recommendations of the Global Alliance on Improving Outcomes of Acne, retinoids such as adapalene are considered first line therapy in acne treatment and are to be used either independently or in conjunction with benzoyl peroxide and/or an antimicrobial agent for maximum efficacy. Not your parents’ acne treatment. Take a different approach to clearing—and preventing—your acne. Non-comedogenic, fragrance-free Differin Gel contains the retinoid adapalene, the first over-the-counter active ingredient for acne in more than 30 years.